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M9490679.TXT
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1994-09-24
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Document 0679
DOCN M9490679
TI The in vivo effect of ellipticine analogues on the blood concentration
of Friend virus: a murine model for studying anti-HIV drugs.
DT 9411
AU Mathe G; Chenu E; Bourut C; Orbach-Arbouys S; Institut du cancer et
d'immunologie, Hopital Suisse de Paris,; Issy-les-Moulineaux, France.
SO Biomed Pharmacother. 1993;47(10):457-60. Unique Identifier : AIDSLINE
MED/94339396
AB The viremia of a mouse carrying a murine retrovirus, the Friend virus,
was taken as a model for screening drugs which could be active on the
human HIV retrovirus. Ellipticine and two of its analogues injected ip
at appropriate doses drastically reduced the viremia of the Friend
virus-injected mice, as measured by transfer of their serum on day 8 of
the treatment to secondary recipients and numeration, in the spleens of
the latter, of the foci the remaining virus had induced. Since phase I
and II trials have already been published (for leukemia treatment), the
efficacy of those drugs on HIV-1 positive AZT-resistant patients can be
tested directly.
DE Acquired Immunodeficiency Syndrome/*DRUG THERAPY Animal
Blood/MICROBIOLOGY Disease Models, Animal Ellipticines/*PHARMACOLOGY
Friend Virus/*DRUG EFFECTS HIV Infections/DRUG THERAPY HIV-1/DRUG
EFFECTS Male Mice Mice, Inbred DBA Zidovudine/PHARMACOLOGY JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).